Microstructure changes of the normal-appearing white matter in the Corpus Callosum in Relapsing-Remitting Multiple Sclerosis
Lester Melie-Garcia1,2,3, Muhamed Barakovic1,2,3, Matthias Weigel1,2,3,4, Reza Rahmanzadeh1,2,3, Riccardo Galbusera1,2,4, Po-Jui Lu1,2,3, Alessandro Cagol1,2,3, Antoine Lutti5, Sabine Schaedelin6, Pascal Benkert6, Alexandra Todea1,2,3,7,8, Esther Ruberte1,9, Ernst-Wilhelm Radue1, Ludwig Kappos1,2,3, Jens Kuhle3, and Cristina Granziera1,2,3
1Translational Imaging in Neurology (ThINK), Biomedical Engineering Department, University of Basel, Basel, Switzerland, 2Department of Medicine, University Hospital Basel, Basel, Switzerland, 3Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, Basel, Switzerland, 4Division of Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland, 5Laboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland, 6Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, Basel, Switzerland, 7Division of Neuroradiology, Department of Radiology, University Hospital Basel, Basel, Switzerland, 8Translational Imaging in Neurology (ThINK) Basel, Biomedical Engineering Department, University of Basel, Basel, Switzerland, 9Medical Image Analysis Center (MIAC), Basel, Switzerland
A scarce body of literature studies the Corpus Callosum (CC) normal-appearing white matter (NAWM) in Relapsing-Remitting Multiple Sclerosis (RRMS). This work aimed to characterize the degree of the alterations in different CC segments by assessing the extent of damage to myelin and axon, as measured with myelin volume fraction, axonal volume fraction, and g-ratio. These microstructural measures correlated with disease duration, EDSS, number, and volume of the lesions in other white matter regions. In sum, this work shows that CC pathology in RRMS patients is related to focal damage and/or diffuse neurodegeneration, which is clinically relevant.
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