Abstract #4513

Iron and Myelin Content in Cortical Lesions in Multiple Sclerosis using Magnetic Susceptibility Source Separation

Jannis Müller^1,2, Po-Jui Lu^1,2, Hyeong-Geol Shin³, Reza Rahmanzadeh^1,2, Charidimos Tsagkas^1,2, Muhamed Barakovic^1,2, Riccardo Galbusera^1,2, Özgür Yaldizli^1,2, Matthias Weigel^1,4, Yi Wang⁵, Thanh Nguyen⁵, Jens Kuhle², Jongho Lee³, and Cristina Granziera^1,2

¹Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Translational Imaging in Neurology (ThINk) Basel, Basel, Switzerland, ²University Hospital Basel and University of Basel, Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Basel, Switzerland, ³Department of Electrical and Computer Engineering, Seoul National University, Laboratory for Imaging Science and Technology, Seoul, Korea, Republic of, ⁴Division of Radiological Physics, Department of Radiology, University Hospital Basel and University of Basel, Basel, Switzerland, ⁵Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States

Synopsis

The visualization and characterization of cortical MS lesions is challenging on conventional MRI. In the present study, we used a susceptibility source separation algorithm to divide the positive and negative susceptibility of quantitative susceptibility mapping (QSM) MRI, so that we could disentangle signal alterations due to myelin loss or iron accumulation. In 19 MS patient with 123 cortical lesions, we found that the major part of QSM susceptibility of cortical lesions is driven by myelin and iron loss, while only a small proportion of lesions (12/123, 9.8%) showed an increment of susceptibility that is caused by iron accumulation.

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