Iron and Myelin Content in Cortical Lesions in Multiple Sclerosis using Magnetic Susceptibility Source Separation
Jannis Müller1,2, Po-Jui Lu1,2, Hyeong-Geol Shin3, Reza Rahmanzadeh1,2, Charidimos Tsagkas1,2, Muhamed Barakovic1,2, Riccardo Galbusera1,2, Özgür Yaldizli1,2, Matthias Weigel1,4, Yi Wang5, Thanh Nguyen5, Jens Kuhle2, Jongho Lee3, and Cristina Granziera1,2
1Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Translational Imaging in Neurology (ThINk) Basel, Basel, Switzerland, 2University Hospital Basel and University of Basel, Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Basel, Switzerland, 3Department of Electrical and Computer Engineering, Seoul National University, Laboratory for Imaging Science and Technology, Seoul, Korea, Republic of, 4Division of Radiological Physics, Department of Radiology, University Hospital Basel and University of Basel, Basel, Switzerland, 5Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States
The visualization and characterization of cortical MS lesions is challenging on conventional MRI. In the present study, we used a susceptibility source separation algorithm to divide the positive and negative susceptibility of quantitative susceptibility mapping (QSM) MRI, so that we could disentangle signal alterations due to myelin loss or iron accumulation. In 19 MS patient with 123 cortical lesions, we found that the major part of QSM susceptibility of cortical lesions is driven by myelin and iron loss, while only a small proportion of lesions (12/123, 9.8%) showed an increment of susceptibility that is caused by iron accumulation.
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