Periventricular tissue damage in multiple sclerosis assessed by quantitative magnetization transfer
Lukas Pirpamer1, Andrej Vovk2, Anna Damulina3, Michael Khalil3, Reinhold Schmidt1, Christian Enzinger4,5, and Stefan Ropele3
1Department of Neurology, Division of Neurogeriatrics, Medical University of Graz, Graz, Austria, 2Medicinska fakulteta, Univerza v Ljubljani, Ljubljana, Slovenia, 3Department of Neurology, Division of General Neurology, Medical University of Graz, Graz, Austria, 4Neurology, Medical University of Graz, Graz, Austria, 5Department of Radiology, Division of Neuroradiology, Medical University of Graz, Graz, Austria
Periventricular tissue damage in multiple sclerosis has been suggested to be mediated by toxic soluble factors in the cerebrospinal-fluid. Magnetization transfer imaging has shown great potential to reveal microstructural tissue changes and has been used to study the association of periventricular normal-appearing white matter (NAWM) changes to the distance from the ventricle. We assessed high-resolution magnetization transfer saturation imaging (MTsat) in equidistant bands around the ventricle of MS patients and compared the resulting MTsat gradient of the thalamus and NAWM. While PV-MTsat values in NAWM are consistent to the literature, MTsat values in the outer thalamic bands were higher than controls, likely caused by increased iron levels.
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