Abstract #4515
Disentangling characteristics of subpial lesions in multiple sclerosis using multiparametric postmortem MRI
Riccardo Galbusera1,2,3, Erik Bahn4, Matthias Weigel1,2,3, Po-Jui Lu1,2,3, Jonas Franz4, Muhamed Barakovic1,2,3, Sabine Schaedelin5, Lester Melie-Garcia1,2,3, Reza Rahmanzadeh1,2,3, Peter Dechent6, Antoine Lutti7, Govind Bhagavatheeshwaran8, Wolfgang Brück4, Ludwig Kappos2,3, Christine Stadelmann4, and Cristina Granziera1,2
1Neurology Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 2Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 3Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB) Basel, University Hospital Basel and University of Basel, Basel, Switzerland, 4Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany, 5Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, 6Department of Cognitive Neurology, MR-Research in Neurosciences, University Medical Center Göttingen, Göttingen, Germany, 7Centre for Research in Neuroscience - Department of Clinical Neurosciences, Laboratoire de recherche en neuroimagerie (LREN) University Hospital and University of Lausanne, Lausanne, Switzerland, 8National Institute of Neurological Disorders and Stroke, Bethesda, MD, Bethesda, MD, United States
Synopsis
We have characterized the imaging correlates of subpial demyelination in the cerebral cortex of MS patients by exploiting multiparametric postmortem qMRI and histopathology. MTsat, qT1 and AD were the measures that best captured subpial lesions pathology. Additionally, we found that some subpial lesions exhibit a juxta-cortical rim of increased susceptibility and show lower MWF than the ones without rim.
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