Abstract #4516

Hypo-diamagnetism on χ-separation: a potential marker for the differential diagnosis between MS and NMOSD.

Jinhee Jang¹, Hyeong-Geol Shin², Hyebin Lee¹, Dohoon Park¹, Junghwa Kang³, Yoonho Nam³, Jongho Lee², and Woojun Kim⁴

¹Radiology, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ²Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ³Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of, ⁴Neurology, Seoul St. Mary's Hospital, Seoul, Korea, Republic of

Synopsis

Using χ-separation, detailed characterization of MS and NMOSD lesions were possible. Majority (490/611, 80%) of MS lesions were hypo-diamagnetic on χ_neg maps, suggesting loss of diamagnetic myelin. On the contrary, only 14.2% (32/225) of NMOSD lesions were hypo-diamagnetic. On χ_pos maps, some MS and a few NMOSD lesions showed paramagnetic rim round the lesion, which was identical to paramagnetic rim sign on SWI or QSM. The proportion of hypo-diamagnetic lesions showed excellent diagnostic performances (AUROC 0.961, 95%CI 0.907-1), as compared to central vein sign and paramagnetic rim lesion sign.

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