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Abstract #4516

Hypo-diamagnetism on χ-separation: a potential marker for the differential diagnosis between MS and NMOSD.

Jinhee Jang1, Hyeong-Geol Shin2, Hyebin Lee1, Dohoon Park1, Junghwa Kang3, Yoonho Nam3, Jongho Lee2, and Woojun Kim4
1Radiology, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, 2Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 3Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of, 4Neurology, Seoul St. Mary's Hospital, Seoul, Korea, Republic of


Using χ-separation, detailed characterization of MS and NMOSD lesions were possible. Majority (490/611, 80%) of MS lesions were hypo-diamagnetic on χneg maps, suggesting loss of diamagnetic myelin. On the contrary, only 14.2% (32/225) of NMOSD lesions were hypo-diamagnetic. On χpos maps, some MS and a few NMOSD lesions showed paramagnetic rim round the lesion, which was identical to paramagnetic rim sign on SWI or QSM. The proportion of hypo-diamagnetic lesions showed excellent diagnostic performances (AUROC 0.961, 95%CI 0.907-1), as compared to central vein sign and paramagnetic rim lesion sign.

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