Demyelination and remyelination in cuprizone mouse model detected by CEST MRI at 3T
Zilin CHEN1, Jianpan HUANG1, Joseph H.C. LAI1, Kai-Hei TSE2, and Kannie W.Y. CHAN1,3,4,5
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, 2Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China, 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, 5Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China
Multiple sclerosis (MS) is a common demyelinating disease that heavily relies on differential diagnosis. Specific CEST contrast is known to be sensitive to alterations in proteins and lipids, the major components of myelin. This includes amide protons at 3.5 ppm and relayed nuclear Overhauser effect (rNOE) at -1.6~-3.5 ppm. Here, we study these CEST contrasts and their uniqueness towards myelin changes in a cuprizone model, which recapitulates remyelination and demyelination in MS. We observed substantial changes of rNOE and amide, during demyelination (P<0.05) and remyelination, indicating great potential of CEST MRI in monitoring myelin change and MS identification at 3T.
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