Multiple sclerosis (MS) is a common demyelinating disease that heavily relies on differential diagnosis. Specific CEST contrast is known to be sensitive to alterations in proteins and lipids, the major components of myelin. This includes amide protons at 3.5 ppm and relayed nuclear Overhauser effect (rNOE) at -1.6~-3.5 ppm. Here, we study these CEST contrasts and their uniqueness towards myelin changes in a cuprizone model, which recapitulates remyelination and demyelination in MS. We observed substantial changes of rNOE and amide, during demyelination (P<0.05) and remyelination, indicating great potential of CEST MRI in monitoring myelin change and MS identification at 3T.
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