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Abstract #4520

Gender-related differences in static and dynamic functional connectivity in multiple sclerosis: a multicenter study

Yao Wang1, Fuqing Zhou1, Yaou Liu2, and Qian Long 3
1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China, 2Department of Radiology, Beijing Tiantan Hospital, Beijing, China, 3MR Research, GE Healthcare, Beijing, China


The study investigated gender-related differences in patients with multiple sclerosis by assessing static and dynamic functional connectivity within large scale functional networks. Our results observed that MS could eliminate the effect of gender on static and dynamic functional connectivity in healthy controls, and affect static connectivity in male patients and dynamic connectivty in female patients. Correlation analyses suggested these characteristics of static and dynamic connectivity were related to disability and gray matter volume. Thus, our findings underline the importance of gender in founctional impairment and reorganization in MS

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