Hippocampal glutathione-glutamate couplings predict cognitive impairment in patients with relapsing-remitting multiple sclerosis
Fuyan Li1, Wei Zong1, Fuxin Ren1, Ning Li1, Xiao Li1, Zongrui Dai2, Weibo Chen3, Muwei Li4, and Fei Gao1
1Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China, 2Westa College, Southwest University, Chongqing, China, 3Philips Healthcare, Shanghai, China, 4Vanderbilt University Institute of Imaging Science, Nashville, TN, United States
Cognitive impairment is a common symptom of MS. GSH and Glu, keeping a homeostasis in the stable stage, were considered as key players in oxidative stress defending and synaptic plasticity, respectively. We aim to explore the changes of GSH and Glu levels and GSH-Glu couplings in RRMS and their association with cognitive impairment. Our findings indicate that oxidative stress and glutamatergic dysfunction may contribute to cognitive impairment of MS in a regional specificity manner. Hippocampal GSH-Glu decoupling may offer a crucial noninvasive measure of early cognitive impairment and provide a new strategy for the treatment of MS patients.
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