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Abstract #4522

Selective Disruption of the Motor Connectome in Non-Familial Amyotrophic Lateral Sclerosis

Sicong Tu1, Arkiev D'Souza1,2, Chenyu Wang1,2, Christina Maher1, Colin Mahoney1, William Huynh1, Michael Barnett1,2,3, and Matthew Kiernan1,3
1Brain and Mind Centre; The University of Sydney, Sydney, Australia, 2Sydney Neuroimaging and Analysis Centre, Sydney, Australia, 3Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia


Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder with a widespread cortical disease signature. ALS patients demonstrate global network alterations in the white matter connectome in the early stage of disease. Selective disruption of cortical motor associated nodes with the thalamus and contralateral motor cortices is present at disease onset. Disease duration is associated with reduced structural interhemispheric cortical motor connectivity. Focal motor abnormalities present in the white matter connectome may be a sensitive marker in the earliest stages of ALS prior to functional decline.

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