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Abstract #4523

Blood-Brain Barrier Leakage in Patients with Alzheimer’s Disease and Dementia with Lewy Bodies

Ziming Xu1, Zhichao Chen2, Lingyun Ma2, Yajie Wang1, Hao Wu3, Hao Lu4, Yong Ji2, and Huijun Chen1
1Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, 2Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China, 3Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China, 4Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China


Previous in vivo studies have shown that dysfunction of blood-brain barrier is highly associated with the process of Alzheimer’s disease (AD), but similar studies in dementia with Lewy bodies (DLB) have rarely been reported. In this study, for the first time, differences of BBB leakage among patients with AD, DLB and age-matched healthy control in different brain regions had been demonstrated, which may serve as one potential tool for diagnosis of different neurodegenerative diseases and contribute to our understanding of their pathophysiological basis.

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