Abstract #4523

Blood-Brain Barrier Leakage in Patients with Alzheimer’s Disease and Dementia with Lewy Bodies

Ziming Xu¹, Zhichao Chen², Lingyun Ma², Yajie Wang¹, Hao Wu³, Hao Lu⁴, Yong Ji², and Huijun Chen¹

¹Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, ²Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China, ³Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China, ⁴Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China

Synopsis

Previous in vivo studies have shown that dysfunction of blood-brain barrier is highly associated with the process of Alzheimer’s disease (AD), but similar studies in dementia with Lewy bodies (DLB) have rarely been reported. In this study, for the first time, differences of BBB leakage among patients with AD, DLB and age-matched healthy control in different brain regions had been demonstrated, which may serve as one potential tool for diagnosis of different neurodegenerative diseases and contribute to our understanding of their pathophysiological basis.

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