Abstract #4525

Predicting conversion from normal aging to mild cognitive impairment using 1H-MRS of posterior cingulate cortex

Anna Kiryanova¹, Andrei Manzhurtsev^1,2,3, Olga Bozhko^2,4, Yana Fedorova⁴, and Natalia Semenova ^1,2,3,5

¹Lomonosov Moscow State University, Moscow, Russian Federation, ²Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, ³Emanuel Institute of Biochemical Physics of RAS, Moscow, Russian Federation, ⁴Mental Health Research Center, Moscow, Russian Federation, ⁵Semenov Federal Research Center of Chemical Physics of the Russian Academy of Sciences., Moscow, Russian Federation

Synopsis

This study aims to identify possible biomarkers of minimal cognitive impairment (MCI) in the posterior cingulate cortex using MR spectroscopy. Absolute concentrations of metabolites such as Cr, NAA, Cho, Glx, Ins were determined in subjects with MCI and in subjects from the normal group. Our study revealed a statistically significant increase in the absolute concentration of choline-containing compounds, as well as the Cho/Cr value in PCC in the MCI group, what may indicate the destruction of cell membranes. The results expand our knowledge in understanding the causes of MCI and are promising for the study of Cho as biomarkers.

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