Abstract #4526

Reduced GABA levels in the medial prefrontal cortex are associated with cognitive impairment in patients with NMOSD

Yang Yang¹, Qiuyu Yu¹, Peng Wu², Hui Dai¹, Xiaojuan Wu¹, Shuting Han¹, and Yonggang Li¹

¹The First Affiliated Hospital of Soochow University, Suzhou, China, ²Philips Healthcare, Shanghai, China

Synopsis

Cognitive impairment is a symptom present in part of patients with neuromyelitis optica spectrum disorder (NMOSD). We demonstrated decreased GABA levels in the medial prefrontal cortex (mPFC) in NMOSD participants compared to healthy controls. The mPFC GABA levels showed significant associations with cognitive performance in patients with NMOSD. This study suggested that the changes in regional GABA levels might be a potential metabolic feature of cognitive decline in patients with NMOSD.

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