Abstract #4536

Utility of advanced diffusion model in early detection of cervical spondylotic myelopathy: a comparison between DTI and NODDI

Meng-Ze Zhang¹, Han-Qiang Ou-Yang^1,2,3, Dan Jin¹, Chun-Jie Wang¹, Jian-Fang Liu¹, Qiang Zhao¹, Xian-Chang Zhang⁴, Xiao-Guang Liu^1,2,3, Zhong-Jun Liu^1,2,3, Ning Lang¹, Xing-Wen Sun¹, Liang Jiang^1,2,3, and Hui-Shu Yuan¹

¹Peking University Third Hospital, Beijing, China, ²Engineering Research Center of Bone and Joint Precision Medicine, Beijing, China, ³Beijing Key Laboratory of Spinal Disease Research, Beijing, China, ⁴MR collaboration, Siemens Healthineers Ltd, Beijing, China

Synopsis

This study compared the sensitivity of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) to detect cervical spondylotic myelopathy (CSM) at an early stage. The results showed that NODDI-based indicators can distinguish patients with CSM without T2-weighted increased signal intensity from healthy controls during internal validation, while DTI-based indicators cannot. These findings suggest that NODDI is a promising method to detect CSM at an early stage.

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