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Abstract #4536

Utility of advanced diffusion model in early detection of cervical spondylotic myelopathy: a comparison between DTI and NODDI

Meng-Ze Zhang1, Han-Qiang Ou-Yang1,2,3, Dan Jin1, Chun-Jie Wang1, Jian-Fang Liu1, Qiang Zhao1, Xian-Chang Zhang4, Xiao-Guang Liu1,2,3, Zhong-Jun Liu1,2,3, Ning Lang1, Xing-Wen Sun1, Liang Jiang1,2,3, and Hui-Shu Yuan1
1Peking University Third Hospital, Beijing, China, 2Engineering Research Center of Bone and Joint Precision Medicine, Beijing, China, 3Beijing Key Laboratory of Spinal Disease Research, Beijing, China, 4MR collaboration, Siemens Healthineers Ltd, Beijing, China


This study compared the sensitivity of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) to detect cervical spondylotic myelopathy (CSM) at an early stage. The results showed that NODDI-based indicators can distinguish patients with CSM without T2-weighted increased signal intensity from healthy controls during internal validation, while DTI-based indicators cannot. These findings suggest that NODDI is a promising method to detect CSM at an early stage.

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