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Abstract #4537

High-spatial assessment of low-level permeability within normal-appearing brain tissue using dual-temporal resolution DCE-MRI

Ka-Loh Li1, Daniel Lewis2, Xiaoping Zhu1, Timothy Cootes1, and Alan Jackson1
1Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom, 2Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom


Quantifying blood-brain barrier permeability in normal-appearing brain through dynamic contrast-enhanced MRI (DCE-MRI) is challenging. We evaluated a new method, which combines the hybrid first-pass Patlak-plot (FP-PP) model with a high spatiotemporal resolution DCE approach termed LEGATOS. Dual-temporal resolution DCE-MRI data in twelve patients with neurofibromatosis type II (NF2) imaged at 1.5T were analyzed, and estimates of Ktrans within normal-appearing grey matter (NAGM) and white matter (NAWM) were compared. This new method permitted high-spatial resolution assessment of low-level permeability in normal-appearing brain and in our NF2 patient cohort a significant positive correlation between tumor volume and NAGM/NAWM Ktrans values was observed.

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