Quantifying blood-brain barrier permeability in normal-appearing brain through dynamic contrast-enhanced MRI (DCE-MRI) is challenging. We evaluated a new method, which combines the hybrid first-pass Patlak-plot (FP-PP) model with a high spatiotemporal resolution DCE approach termed LEGATOS. Dual-temporal resolution DCE-MRI data in twelve patients with neurofibromatosis type II (NF2) imaged at 1.5T were analyzed, and estimates of Ktrans within normal-appearing grey matter (NAGM) and white matter (NAWM) were compared. This new method permitted high-spatial resolution assessment of low-level permeability in normal-appearing brain and in our NF2 patient cohort a significant positive correlation between tumor volume and NAGM/NAWM Ktrans values was observed.
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