Abstract #4540
Free-water volume fraction increases nonlinearly across the lifespan in healthy human brain white matter areas
Tomasz Pieciak1, Guillem París1, Dani Beck2,3, Ivan I. Maximov3,4, Antonio Tristán-Vega1, Rodrigo de Luis-García1, Lars T. Westlye2,3,5, and Santiago Aja-Fernández1
1Laboratorio de Procesado de Imagen (LPI), Universidad de Valladolid, Valladolid, Spain, 2Department of Psychology, University of Oslo, Oslo, Norway, 3NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 4Western Norway University of Applied Sciences, Bergen, Norway, 5KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway
Synopsis
The free-water (FW) volume fraction $$$f$$$ is a sensitive diffusion MRI biomarker correlated with microstructural alterations in the human brain. This paper studies the variations in the FW volume fraction $$$f$$$ in healthy human brain white matter (WM) across the lifespan from a set of 248 female and 140 male subjects. Our study reveals positive nonlinear correlations of the volume fraction $$$f$$$ with age over the WM regions and suggests a heteroscedastic nature and age-dependent intra-region-of-interest variability of $$$f$$$ across the lifespan.
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