Abstract #4540

Free-water volume fraction increases nonlinearly across the lifespan in healthy human brain white matter areas

Tomasz Pieciak¹, Guillem París¹, Dani Beck^2,3, Ivan I. Maximov^3,4, Antonio Tristán-Vega¹, Rodrigo de Luis-García¹, Lars T. Westlye^2,3,5, and Santiago Aja-Fernández¹

¹Laboratorio de Procesado de Imagen (LPI), Universidad de Valladolid, Valladolid, Spain, ²Department of Psychology, University of Oslo, Oslo, Norway, ³NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ⁴Western Norway University of Applied Sciences, Bergen, Norway, ⁵KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway

Synopsis

The free-water (FW) volume fraction $$$f$$$ is a sensitive diffusion MRI biomarker correlated with microstructural alterations in the human brain. This paper studies the variations in the FW volume fraction $$$f$$$ in healthy human brain white matter (WM) across the lifespan from a set of 248 female and 140 male subjects. Our study reveals positive nonlinear correlations of the volume fraction $$$f$$$ with age over the WM regions and suggests a heteroscedastic nature and age-dependent intra-region-of-interest variability of $$$f$$$ across the lifespan.

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