Abstract #4539

White matter hyperintensities and brain volume changes in Cushing disease and related risk factors

Yue Wu¹, Weiwei Wang¹, Shiman Wu¹, Qing Li², Zhenwei Yao¹, and Zengyi Ma³

¹Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China, ²MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, ³Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

Synopsis

Cushing's disease(CD) has significantly more white matter hyperintensities and enlarged perivascular spaces, compare to same-aged healthy subjects. Age, diabetes, hypokalemia was significantly related with white matter hyperintensities in CD. The gray matter volume of CD patients was significantly smaller than the healthy subjects. Compared with patients with type 2 diabetes alone, the mean age of CD with diabetes were younger with shorter course of disease, but with more severe white matter damage. the severity of white matter hyperintensities were ranked as belowed: CD with type 2 diabetes, CD without type 2 diabetes, type 2 diabetes.

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