White matter hyperintensities and brain volume changes in Cushing disease and related risk factors
Yue Wu1, Weiwei Wang1, Shiman Wu1, Qing Li2, Zhenwei Yao1, and Zengyi Ma3
1Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China, 2MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, 3Department of Neurosurgery, National Center for Neurological Disorders (NCND), Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Cushing's disease(CD) has significantly more white matter hyperintensities and enlarged perivascular spaces, compare to same-aged healthy subjects. Age, diabetes, hypokalemia was significantly related with white matter hyperintensities in CD. The gray matter volume of CD patients was significantly smaller than the healthy subjects. Compared with patients with type 2 diabetes alone, the mean age of CD with diabetes were younger with shorter course of disease, but with more severe white matter damage. the severity of white matter hyperintensities were ranked as belowed: CD with type 2 diabetes, CD without type 2 diabetes, type 2 diabetes.
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