Abstract #4545

Severe Cerebral Small Vessel Disease Burden is Associated with Brain Hypo-perfusion, and higher Framingham Risk score: An 8 year follow-up study

Xiaoqian Zhang¹, Sirui Liu¹, Feng Feng¹, and Zhentao Zuo^2,3

¹Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ³Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Peking Union Medical College, Beijing, China

Synopsis

The study investigated relationship between cerebral small vessel disease (CSVD) burden, cerebral blood flow (CBF) and cardiovascular risk in the aging brains with normal cognitive function at baseline and conducted telephone cognitive follow-up for nearly 8 years. The results showed that severe CSVD burden was significantly associated with higher cardiovascular risk scores and decreased CBF in multiple areas, with involvement of nearly all cortical brain areas. Subjects with severe CSVD burden were more likely to suffer from long-term cognitive decline. This suggests the capability of CSVD burden serving as an imaging marker of predicting cognitive decline.

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