Acceleration Motion Compensation Diffusion-weighted Imaging for Large Vessel Vasculitis: Phantom Model and Initial Clinical Experience
Tomoko Hyodo1, Daisuke Morimoto-Ishikawa2,3, Hayato Kaida1, Yu Ueda4, Daisuke Tomita5, Atsuhiro Yamamoto5, Makoto Itoh2, Nao Yasuda2, Hiroyuki Fukushima2, Yuji Nozaki5, Itaru Matsumura5, and Kazunari Ishii1
1Radiology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan, 2Radiology Center, Kindai University Hospital, Osaka-Sayama, Japan, 3Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Japan, 4Philips Japan, Tokyo, Japan, 5Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan
The ascending aorta is poorly delineated on DWI due to the heartbeat, making it difficult to assess the activity of large vessel vasculitis using MRI. We investigated the utility of acceleration motion compensation diffusion-weighted imaging (aMC-DWI) compared with conventional DWI (cDWI) to detect active inflammation of the accenting aorta. The phantom experiment revealed that aMC-DWI showed a significantly higher median visual score than cDWI in both experimenters (P =.048 for both). The clinical study on 11 patients showed that aMC-DWI had higher sensitivity, specificity, and positive predictive value (with FDG-PET/CT as the reference method) than cDWI.
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