Abstract #4546

Acceleration Motion Compensation Diffusion-weighted Imaging for Large Vessel Vasculitis: Phantom Model and Initial Clinical Experience

Tomoko Hyodo¹, Daisuke Morimoto-Ishikawa^2,3, Hayato Kaida¹, Yu Ueda⁴, Daisuke Tomita⁵, Atsuhiro Yamamoto⁵, Makoto Itoh², Nao Yasuda², Hiroyuki Fukushima², Yuji Nozaki⁵, Itaru Matsumura⁵, and Kazunari Ishii¹

¹Radiology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan, ²Radiology Center, Kindai University Hospital, Osaka-Sayama, Japan, ³Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita, Japan, ⁴Philips Japan, Tokyo, Japan, ⁵Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan

Synopsis

The ascending aorta is poorly delineated on DWI due to the heartbeat, making it difficult to assess the activity of large vessel vasculitis using MRI. We investigated the utility of acceleration motion compensation diffusion-weighted imaging (aMC-DWI) compared with conventional DWI (cDWI) to detect active inflammation of the accenting aorta. The phantom experiment revealed that aMC-DWI showed a significantly higher median visual score than cDWI in both experimenters (P =.048 for both). The clinical study on 11 patients showed that aMC-DWI had higher sensitivity, specificity, and positive predictive value (with FDG-PET/CT as the reference method) than cDWI.

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