Abstract #4565

Simultaneous late-gadolinium enhancement and T1 mapping to detect diffuse myocardial fibrosis in 1K/DOCA/salt-induced mice using MP2RAGE

Gang Zheng¹, Yifang Li², Ekaterina Salimova ¹, Hong X Wang¹, Shenjun Zhong ¹, Chrishan S Samuel ², Michael de Veer¹, and Gary Egan ¹

¹Monash Biomedical Imaging, Monash University, Clayton, Australia, ²Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Australia

Synopsis

The detection and localization of diffuse myocardial fibrosis is for the non-invasive evaluation of therapeutic strategies in murine cardiac disease models. Cardiac late-gadolinium enhancement (LGE) and T1 mapping are two techniques for non-invasive cardiovascular magnetic resonance (CMR) imaging. This abstract demonstrates that the magnetization prepared 2 rapid acquisition gradient echo (MP2RAGE) can simultaneously acquire LGE and T1 maps for the detection of diffuse myocardial fibrosis in a 1K/DOCA/salt-induced murine model of hypertensive disease.

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