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Abstract #4565

Simultaneous late-gadolinium enhancement and T1 mapping to detect diffuse myocardial fibrosis in 1K/DOCA/salt-induced mice using MP2RAGE

Gang Zheng1, Yifang Li2, Ekaterina Salimova 1, Hong X Wang1, Shenjun Zhong 1, Chrishan S Samuel 2, Michael de Veer1, and Gary Egan 1
1Monash Biomedical Imaging, Monash University, Clayton, Australia, 2Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Australia


The detection and localization of diffuse myocardial fibrosis is for the non-invasive evaluation of therapeutic strategies in murine cardiac disease models. Cardiac late-gadolinium enhancement (LGE) and T1 mapping are two techniques for non-invasive cardiovascular magnetic resonance (CMR) imaging. This abstract demonstrates that the magnetization prepared 2 rapid acquisition gradient echo (MP2RAGE) can simultaneously acquire LGE and T1 maps for the detection of diffuse myocardial fibrosis in a 1K/DOCA/salt-induced murine model of hypertensive disease.

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