This study mainly investigated the feasibility of 3D pseudo-continuous arterial spin labeling (3D-pCASL) imaging in predicting the treatment response to chemoradiotherapy (CRT) for advanced nasopharyngeal carcinoma (ANPC) patients. 3D-pCASL derived blood flow (BF)s in tumors were respectively obtained for patients in response group (RG) and no-response group (NRG). The resultant pre-treatment BF showed significantly different values between RG and NRG patients. Combining with clinical information, BF also showed robust prediction between RG and NRG patients. Therefore, 3D-pCASL could be considered an effective method in tumor response prediction to CRT for ANPC patients before clinical treatment.
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