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Abstract #4578

A study on MRI arterial spin labeling in predicting early response to chemoradiotherapy in patients with advanced nasopharyngeal carcinoma

zongqiong sun1 and Weiqiang Dou2
1Department of radiology, Affiliated hospital of Jiangnan university, Wuxi, China, 2GE healthcare,MR research China, Beijing, China


This study mainly investigated the feasibility of 3D pseudo-continuous arterial spin labeling (3D-pCASL) imaging in predicting the treatment response to chemoradiotherapy (CRT) for advanced nasopharyngeal carcinoma (ANPC) patients. 3D-pCASL derived blood flow (BF)s in tumors were respectively obtained for patients in response group (RG) and no-response group (NRG). The resultant pre-treatment BF showed significantly different values between RG and NRG patients. Combining with clinical information, BF also showed robust prediction between RG and NRG patients. Therefore, 3D-pCASL could be considered an effective method in tumor response prediction to CRT for ANPC patients before clinical treatment.

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