Abstract #4577
Does arterial spin labeling provide insights into long-term effects of radiation therapy in the healthy brain?
Andrea Kronfeld1, Alexandra Russo2, Nicole Henninger2, Arthur Wingerter2, Moritz Brunk2, Kaml Khawaja1, Andrei Tropine1, Abdulghani Moussa Pacha1, Violeta Dimova3, Federico Marini4,5, Doris Leithner6, Sabine Nospes7, Roman Kloeckner8, Felix Hahn8, Marcus Stockinger9, Heinz Schmidberger9, Marc Brockmann1, Marie Astrid Neu2, Joerg Faber2, and Yasemin Tanyildizi1
1Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 2Pediatric Hematology, Oncology & Hemostaseology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 3Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 4Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 5Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 6Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany, 7Otolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 8Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, 9Radiation Oncology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
Synopsis
28 patients after earlier (1-45 years) whole brain radiation and 22 healthy controls were examined by arterial spin labeling to discover insights ASL could give in long-term effects of radiation therapy in the healthy brain. Relative cerebral blood flow and relative bolus arrival time showed increased values compared to the healthy control, which could be a sign for increased permeability and thickening of the vessels, two well described effects of radiation therapy ASL gives insight into.
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