Acetazolamide-augmented blood-oxygen-level-dependent (ACZ-BOLD MRI) provides robust estimation of cerebrovascular reactivity (CVR). Past approaches are limited to extraction of terminal CVR at arbitrarily selected times in the pharmacologic response, due to low signal-to-noise characteristics. We previously introduced a computational framework that pre-conditions the BOLD response for dynamic analysis and extraction of maximal, rather than terminal augmentation profiles, and novel hemodynamic signatures such as ACZ-BOLD time-to-maxima (Tmax). Several consistent and sometimes paradoxical patterns have emerged, the presentation of which we considered timely for this potentially novel hemodynamic neuroimaging biomarker.
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