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Abstract #4581

Revealing Occult Hemodynamic Signatures from the Acetazolamide-Augmented Cerebral BOLD Response

Siddhant Dogra1, Xiuyuan Wang2, Jelle Veraart1, Alejandro Gupta1, Koto Ishida3, Deqiang Qiu4, and Seena Dehkharghani1,3
1Department of Radiology, New York University Langone Health, New York, NY, United States, 2Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 3Department of Neurology, New York University Langone Health, New York, NY, United States, 4Department of Radiology, Emory University, Atlanta, GA, United States


Acetazolamide-augmented blood-oxygen-level-dependent (ACZ-BOLD MRI) provides robust estimation of cerebrovascular reactivity (CVR). Past approaches are limited to extraction of terminal CVR at arbitrarily selected times in the pharmacologic response, due to low signal-to-noise characteristics. We previously introduced a computational framework that pre-conditions the BOLD response for dynamic analysis and extraction of maximal, rather than terminal augmentation profiles, and novel hemodynamic signatures such as ACZ-BOLD time-to-maxima (Tmax). Several consistent and sometimes paradoxical patterns have emerged, the presentation of which we considered timely for this potentially novel hemodynamic neuroimaging biomarker.

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