Abstract #4583

Are cerebral microvascular perfusion and diffusion dynamics associated with neurological function in acute ischemic stroke?

Fei Chen¹, Zhenyu Dai¹, Lizheng Yao¹, Congsong Dong¹, Haicun Shi², and Weiqiang Dou³

¹Department of Radiology, the Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, China, ²Department of Neurology, the Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, China, ³GE Healthcare, MR Research China, Beijing, China

Synopsis

This work explored the association of cerebral microvascular perfusion and diffusion dynamics measured by intravoxel incoherent motion (IVIM) imaging with initial neurological function and clinical outcome in acute stroke patients. Significant negative correlations were revealed between IVIM derived diffusion dynamics parameters and initial neurological function as well as clinical outcome for patients with acute ischemic stroke. However, no similar statistical correlation was found for parameters related to microvascular perfusion. IVIM may be therefore suggested as an effective non-invasive method for evaluating the initial neurological function and clinical outcome in acute ischemic stroke.

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