The recent development of relative cerebrovascular reactivity (rCVR) mapping derived from task-free resting-state blood-oxygenation-level-dependent fMRI resolves issues of experimental complications from hypercapnic challenge or pharmacological administrations required in conventional CVR mapping. While human clinical rCVR studies have begun, there lacks rCVR characterization in healthy adult rodents before it can be applied to preclinical models of neuropathology for translational research. This study demonstrated the feasibility of rCVR mapping using resting-state fMRI at 7 Tesla in mice. The results also revealed potential rCVR lateralization in cortical regions and heterogenous vascularization along the septotemporal axis of the hippocampus.
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