Abstract #4596

Accuracy of Characterizing Carotid Vulnerable Atherosclerotic Plaque by 3D MR Vessel Wall Imaging: A Histological Validation Study

Chenlin Du¹, Zihan Ning¹, Huiyu Qiao¹, Shuo Chen¹, Tao Wang², Jingli Cao³, Huo Ran⁴, Dongye Li⁵, Chunjiang Hu¹, Shuwan Yu¹, Hualu Han¹, Rui Shen¹, Dandan Yang^1,6,7, Cancheng Liu⁸, Peng Wu⁹, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ²Department of Neurosurgery, Peking University Third Hospital, Beijing, China, ³China National Clinical Research Center for Neurological Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁴Department of Radiology, Peking University Third Hospital, Beijing, China, ⁵Department of Radiology, Sun Yat-Sen Memorial hospital, Sun Yat-Sen University, Guangzhou, China, ⁶Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China, ⁷Department of Radiology, Beijing Geriatric Hospital, Beijing, China, ⁸Thorough Images, Beijing, China, ⁹Philips Healthcare, Shanghai, China

Synopsis

This study investigated the accuracy of 3D multi-contrast MR vessel wall imaging (VWI) in characterizing carotid vulnerable plaque compositions including lipid-rich necrotic core (LRNC), intraplaque hemorrhage (IPH) and calcification (CA) validated by histology. Good agreements were found between MR and histology in identifying LRNC (κ=0.67), IPH (κ=0.66), and CA (κ=0.62) after excluding histological sections with the plaque components <1.77 mm². Moderate agreements were reached in quantifying plaque compositions with r values ranged from 0.46 to 0.61 (LRNC: r=0.52; IPH: r=0.6; CA: r=0.46). Our study demonstrated that 3D multi-contrast MR VWI is capable of accurately characterizing carotid vulnerable atherosclerotic plaques.

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