Accuracy of Characterizing Carotid Vulnerable Atherosclerotic Plaque by 3D MR Vessel Wall Imaging: A Histological Validation Study
Chenlin Du1, Zihan Ning1, Huiyu Qiao1, Shuo Chen1, Tao Wang2, Jingli Cao3, Huo Ran4, Dongye Li5, Chunjiang Hu1, Shuwan Yu1, Hualu Han1, Rui Shen1, Dandan Yang1,6,7, Cancheng Liu8, Peng Wu9, and Xihai Zhao1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2Department of Neurosurgery, Peking University Third Hospital, Beijing, China, 3China National Clinical Research Center for Neurological Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4Department of Radiology, Peking University Third Hospital, Beijing, China, 5Department of Radiology, Sun Yat-Sen Memorial hospital, Sun Yat-Sen University, Guangzhou, China, 6Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China, 7Department of Radiology, Beijing Geriatric Hospital, Beijing, China, 8Thorough Images, Beijing, China, 9Philips Healthcare, Shanghai, China
This study investigated the accuracy of 3D multi-contrast MR vessel wall imaging (VWI) in characterizing carotid vulnerable plaque compositions including lipid-rich necrotic core (LRNC), intraplaque hemorrhage (IPH) and calcification (CA) validated by histology. Good agreements were found between MR and histology in identifying LRNC (κ=0.67), IPH (κ=0.66), and CA (κ=0.62) after excluding histological sections with the plaque components <1.77 mm2. Moderate agreements were reached in quantifying plaque compositions with r values ranged from 0.46 to 0.61 (LRNC: r=0.52; IPH: r=0.6; CA: r=0.46). Our study demonstrated that 3D multi-contrast MR VWI is capable of accurately characterizing carotid vulnerable atherosclerotic plaques.
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