Abstract #4597

3D Large-Coverage Simultaneous QUantitative T1-T2-T2* Mapping (LC-SQUMA) of Carotid Vessel Wall

Huiyu Qiao¹, Qiansu Yang², Shuo Chen¹, Zihan Ning¹, Hualu Han¹, Rui Shen¹, Peng Wu³, Huijun Chen¹, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine Tsinghua University, Beijing, China, ²Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, China, ³Philips Healthcare, Shanghai, China

Synopsis

MR T1-, T2-, and T2*- mapping have been used to characterize carotid plaques. In this study, we realized a 3D Large-Coverage (longitudinal coverage: 160 mm) Simultaneous QUantitative T1-T2-T2* Mapping (LC-SQUMA) sequence with 0.8 mm isotropic spatial resolution. The LC-SQUMA sequence showed excellent agreements with reference imaging in measuring T1 (R²=0.96), T2 (R²=0.85) and T2* (R²=0.90) values. No significant difference was found in measuring T1, T2 and T2* values (all P>0.05) of cervical muscle between LC-SQUMA sequence and clinical referenced quantitative imaging sequences. The 3D LC-SQUMA sequence is feasible in the large-coverage carotid vessel wall quantitative imaging with isotropic spatial resolution.

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