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Abstract #4597

3D Large-Coverage Simultaneous QUantitative T1-T2-T2* Mapping (LC-SQUMA) of Carotid Vessel Wall

Huiyu Qiao1, Qiansu Yang2, Shuo Chen1, Zihan Ning1, Hualu Han1, Rui Shen1, Peng Wu3, Huijun Chen1, and Xihai Zhao1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine Tsinghua University, Beijing, China, 2Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, China, 3Philips Healthcare, Shanghai, China


MR T1-, T2-, and T2*- mapping have been used to characterize carotid plaques. In this study, we realized a 3D Large-Coverage (longitudinal coverage: 160 mm) Simultaneous QUantitative T1-T2-T2* Mapping (LC-SQUMA) sequence with 0.8 mm isotropic spatial resolution. The LC-SQUMA sequence showed excellent agreements with reference imaging in measuring T1 (R2=0.96), T2 (R2=0.85) and T2* (R2=0.90) values. No significant difference was found in measuring T1, T2 and T2* values (all P>0.05) of cervical muscle between LC-SQUMA sequence and clinical referenced quantitative imaging sequences. The 3D LC-SQUMA sequence is feasible in the large-coverage carotid vessel wall quantitative imaging with isotropic spatial resolution.

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