MR T1-, T2-, and T2*- mapping have been used to characterize carotid plaques. In this study, we realized a 3D Large-Coverage (longitudinal coverage: 160 mm) Simultaneous QUantitative T1-T2-T2* Mapping (LC-SQUMA) sequence with 0.8 mm isotropic spatial resolution. The LC-SQUMA sequence showed excellent agreements with reference imaging in measuring T1 (R2=0.96), T2 (R2=0.85) and T2* (R2=0.90) values. No significant difference was found in measuring T1, T2 and T2* values (all P>0.05) of cervical muscle between LC-SQUMA sequence and clinical referenced quantitative imaging sequences. The 3D LC-SQUMA sequence is feasible in the large-coverage carotid vessel wall quantitative imaging with isotropic spatial resolution.
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