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Abstract #4602

Assessment of cerebrovascular related tissue pH in patients with moyamoya disease: an amide proton transfer weighted imaging study

Chao Xia1,2, Jiaxin Zeng1,2, Xia Wei1,2, Ziyu Li1,2, Yuan Sun1,2, Na Hu1,2, Yi Liu3, Kai Ai4, and Su Lui1,2
1Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China, 3Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China, 4Philips Healthcare, Xi'an, China


The amide proton transfer weighted (APTw) imaging was used to investigate the collateral circulation change and pH alteration in patients with moyamoya disease (MMD). Thirteen patients underwent computed tomography perfusion (CTP), digital subtraction angiography (DSA), and APTw imaging. We analyzed the difference in APTw values between the cerebral and cerebellar hemispheres. Then subgroup analysis was conducted according to the stage of preinfarction period based on CTP. The results revealed that APTw values were significantly lower in cerebral hemispheres than those in cerebellar hemispheres. However, no significant difference in APTw values among patients with different stages of preinfarction period was found.

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