The amide proton transfer weighted (APTw) imaging was used to investigate the collateral circulation change and pH alteration in patients with moyamoya disease (MMD). Thirteen patients underwent computed tomography perfusion (CTP), digital subtraction angiography (DSA), and APTw imaging. We analyzed the difference in APTw values between the cerebral and cerebellar hemispheres. Then subgroup analysis was conducted according to the stage of preinfarction period based on CTP. The results revealed that APTw values were significantly lower in cerebral hemispheres than those in cerebellar hemispheres. However, no significant difference in APTw values among patients with different stages of preinfarction period was found.
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