Abstract #4603

Mapping functional connectivity and brain network changes in hypertensive using resting-state fMRI

Yu-Chen Chuang^1,2, Wen-Chau Wu^1,3, Vincent Chin-Hung Chen^4,5, Yen-Hsuan Hsu⁶, and Jun-Cheng Weng^2,5,7

¹Institute of Medical Device and Imaging, Graduate Institute of Clinical Medicine, National Taiwan University, Taipei city, Taiwan, ²Department of Medical Imaging and Radiological Sciences, Graduate Institute of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, ³Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, ⁴School of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁵Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁶Department of Psychology, National Chung Cheng University, Chiayi, Taiwan, ⁷Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Synopsis

Although understanding of the relationship between cardiovascular disease and brain dysfunction has improved significantly over the past decades, it remains unclear whether hypertension can be a potential risk factor for cognitive impairment. This study tried to use resting-state fMRI to explore the association between hypertensive (HTN) and brain function alterations. We found significant differences in the DMN subsystems in HTN group compared with control group. We also observed higher assortativity in HTN group.

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