Mapping functional connectivity and brain network changes in hypertensive using resting-state fMRI
Yu-Chen Chuang1,2, Wen-Chau Wu1,3, Vincent Chin-Hung Chen4,5, Yen-Hsuan Hsu6, and Jun-Cheng Weng2,5,7
1Institute of Medical Device and Imaging, Graduate Institute of Clinical Medicine, National Taiwan University, Taipei city, Taiwan, 2Department of Medical Imaging and Radiological Sciences, Graduate Institute of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, 3Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 4School of Medicine, Chang Gung University, Taoyuan, Taiwan, 5Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 6Department of Psychology, National Chung Cheng University, Chiayi, Taiwan, 7Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Although understanding of the relationship between cardiovascular disease and brain dysfunction has improved significantly over the past decades, it remains unclear whether hypertension can be a potential risk factor for cognitive impairment. This study tried to use resting-state fMRI to explore the association between hypertensive (HTN) and brain function alterations. We found significant differences in the DMN subsystems in HTN group compared with control group. We also observed higher assortativity in HTN group.
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