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Abstract #4604

Reduced Blood Brain Barrier Water Exchange and Cerebral Blood Flow in CARASIL Patients Revealed by Perfusion MRI: a pilot study

Huiru Pan1,2, Yingying Li3, Huilou Liang1,2, Tingyan Yao4, Xingfeng Shao5, Xuejia Jia3, Zihao Zhang1,2,6, Zhentao Zuo1,2,6, Jing An7, Danny JJ Wang5, Rong Xue1,2,8, and Qi Yang3
1Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China, 4Department of Neurology, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China, 5Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 6The Innovation Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China, 7Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 8Beijing Institute for Brain Disorders, Beijing, China


We applied 3D diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) to evaluate water exchange rate (kw) of blood brain barrier (BBB) and its association with clinical characteristics of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) patients. The CARASIL group showed significantly decreased kw and cerebral blood flow (CBF) compared with healthy controls. The association between kw with age, CBF and white matter hyperintensity volumes (WMH) found in CARASIL patients suggest that kw could be a potential non-contrast imaging biomarker for BBB dysfunction in cerebral small vessel disease.

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