Assessment of Cerebral Perfusion in Moyamoya Disease with Dynamic pCASL using a Variable-TR scheme with Optimized Background Suppression
Osamu Togao1, Makoto Obara2, Kazufumi Kikuchi3, Tatsuhiro Wada4, Chiaki Tokunaga4, Ryoji Mikayama4, Shingo Baba3, Marc Van Cauteren5, Akio Hiwatashi3, and Kousei Ishigami3
1Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Philips Japan, Tokyo, Japan, 3Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 4Division of Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 5Philips Healthcare, Tokyo, Japan
The aim of the present study was to determine whether the dynamic pCASL using a variable-TR scheme with optimized background suppression is useful for assessing cerebral perfusion in patients with Moyamoya disease by comparing with 123I-IMP SPECT. ASL dynamic data at 10 time points are acquired by changing the label duration and post label delay. Significant correlations were found between SPECT-CBF and ASL-CBF and between arterial transit time (ATT) and cerebrovascular reactivity (CVR) to acetazolamide challenge on SPECT. ATT was significantly longer in areas where the CVR was decreased than in areas where the CVR was maintained.
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