Abstract #4606

Assessment of Cerebral Perfusion in Moyamoya Disease with Dynamic pCASL using a Variable-TR scheme with Optimized Background Suppression

Osamu Togao¹, Makoto Obara², Kazufumi Kikuchi³, Tatsuhiro Wada⁴, Chiaki Tokunaga⁴, Ryoji Mikayama⁴, Shingo Baba³, Marc Van Cauteren⁵, Akio Hiwatashi³, and Kousei Ishigami³

¹Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Philips Japan, Tokyo, Japan, ³Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁴Division of Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁵Philips Healthcare, Tokyo, Japan

Synopsis

The aim of the present study was to determine whether the dynamic pCASL using a variable-TR scheme with optimized background suppression is useful for assessing cerebral perfusion in patients with Moyamoya disease by comparing with ¹²³I-IMP SPECT. ASL dynamic data at 10 time points are acquired by changing the label duration and post label delay. Significant correlations were found between SPECT-CBF and ASL-CBF and between arterial transit time (ATT) and cerebrovascular reactivity (CVR) to acetazolamide challenge on SPECT. ATT was significantly longer in areas where the CVR was decreased than in areas where the CVR was maintained.

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