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Abstract #4607

Histogram-based analysis of perfusion features in oligodendrogliomas using multi-delay arterial spin labeling MR imaging: a preliminary study

Huilou Liang1,2, Lianwang Li3,4, Shengyu Fang3,4, Yinyan Wang3,4, Yuchao Liang3,4, Zeshan Yao5, Jing An6, Yan Zhuo1,2,7, Lei Wang3,4, Lijuan Zhang8, Danny JJ Wang9, and Rong Xue1,2,10
1State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Beijing Neurosurgical Institute, Beijing, China, 4Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China, 5AnImage Tech. Beijing Co., Ltd., Beijing, China, 6Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 7CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China, 8Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 9Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 10Beijing Institute for Brain Disorders, Beijing, China


The clinical treatment and prognosis of oligodendrogliomas are closely related to the histopathological grade. As a non-invasive and non-contrast perfusion imaging technique, arterial spin labeling (ASL) has been widely used in studies of glioma grading. The estimation of cerebral blood flow (CBF) in conventional single-delay ASL can be affected by the arterial transit time (ATT) effect. Here, multi-delay 3D ASL providing multiple hemodynamic parameters including ATT and ATT-corrected CBF was used to analyze the histogram-based perfusion features in oligodendrogliomas. Our results showed no difference in rCBF between WHO grade 2 and 3 oligodendrogliomas, but prolonged rATT in higher grade oligodendrogliomas.

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