Abstract #4607

Histogram-based analysis of perfusion features in oligodendrogliomas using multi-delay arterial spin labeling MR imaging: a preliminary study

Huilou Liang^1,2, Lianwang Li^3,4, Shengyu Fang^3,4, Yinyan Wang^3,4, Yuchao Liang^3,4, Zeshan Yao⁵, Jing An⁶, Yan Zhuo^1,2,7, Lei Wang^3,4, Lijuan Zhang⁸, Danny JJ Wang⁹, and Rong Xue^1,2,10

¹State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³Beijing Neurosurgical Institute, Beijing, China, ⁴Department of Neurosurgery, Beijing Tiantan Hospital, Beijing, China, ⁵AnImage Tech. Beijing Co., Ltd., Beijing, China, ⁶Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, ⁷CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China, ⁸Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ⁹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ¹⁰Beijing Institute for Brain Disorders, Beijing, China

Synopsis

The clinical treatment and prognosis of oligodendrogliomas are closely related to the histopathological grade. As a non-invasive and non-contrast perfusion imaging technique, arterial spin labeling (ASL) has been widely used in studies of glioma grading. The estimation of cerebral blood flow (CBF) in conventional single-delay ASL can be affected by the arterial transit time (ATT) effect. Here, multi-delay 3D ASL providing multiple hemodynamic parameters including ATT and ATT-corrected CBF was used to analyze the histogram-based perfusion features in oligodendrogliomas. Our results showed no difference in rCBF between WHO grade 2 and 3 oligodendrogliomas, but prolonged rATT in higher grade oligodendrogliomas.

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