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Abstract #4610

Altered dynamic cerebral perfusion during recovery in right hemisphere subcortical stroke

Peifang Miao1, Caihong Wang1, Ying Wei1, Jingliang Cheng1, and Kaiyu Wang2
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2GE Healthcare MR Research, Beijing, China, Beijing, China


To quantify cerebral blood flow (CBF) dynamic evolution and the relationship with clinical outcomes during recovery in right subcortical stroke patients,ASL and neurological examinations were performed repeatedly in 25 patients at 4 time points and 26 healthy controls (HCs) once.One-way Within-Subjects ANOVA and two sample test,pearson correlation analyses were performed.Compared with HCs, patients displayed continuous crossed cerebellar diaschisis.Increased CBF of contralesional sensorimotor cortex in the subacute and chronic are vital for recovery.Patients showed dynamic changes of CBF in contralesional cerebellum superior and occipital lobe,which were negatively correlated with memory.Findings provide a theoretical basis for functional impairment and recovery after stroke.

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