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Abstract #4614

Comparison of time-encoded and sequential variable-TR scheme for multi-delay pseudo-continuous arterial spin labeling

Makoto Obara1, Osamu Togao2, Lena Vaclavu3, Tatsuhiro Wada4, Chiaki Tokunaga4, Ryoji Mikayama4, Hiroshi Hamano1, Matthias van Osch3, Kim van de Ven5, and Marc Van Cauteren6
1Philips Japan, Tokyo, Japan, 2Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences,, Kyushu University, Fukuoka, Japan, 3C.J. Gorter center for high field MRI, department of Radiology,, Leiden University Medical Center, Leiden, Netherlands, 4Division of Radiology, Department of Medical Technology,, Kyushu University Hospital, Fukuoka, Japan, 5Philips Healthcare, Best, Netherlands, 6Philips Healthcare, Tokyo, Japan


There are two approaches proposed to calculate cerebral blood flow (CBF) and arterial transit time (ATT) accurately, while ensuring sufficient SNR. One is time-encoded (TE) and the other is sequential variable-TR (vTR) pseudo-continuous arterial spin labeling (PCASL). In this study, we measured SNR, CBF, and ATT from these two methods and compared and verified their validity in 5 healthy subjects. The higher SNR was secured in TE-PCASL compared to vTR-PCASL. On the other hand, ATT calculated from vTR-PCASL showed higher correlation coefficient with reference compared with TE-PCASL. The CBF calculated from both schemes showed high correlation coefficient with reference.

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