Abstract #4614

Comparison of time-encoded and sequential variable-TR scheme for multi-delay pseudo-continuous arterial spin labeling

Makoto Obara¹, Osamu Togao², Lena Vaclavu³, Tatsuhiro Wada⁴, Chiaki Tokunaga⁴, Ryoji Mikayama⁴, Hiroshi Hamano¹, Matthias van Osch³, Kim van de Ven⁵, and Marc Van Cauteren⁶

¹Philips Japan, Tokyo, Japan, ²Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences,, Kyushu University, Fukuoka, Japan, ³C.J. Gorter center for high field MRI, department of Radiology,, Leiden University Medical Center, Leiden, Netherlands, ⁴Division of Radiology, Department of Medical Technology,, Kyushu University Hospital, Fukuoka, Japan, ⁵Philips Healthcare, Best, Netherlands, ⁶Philips Healthcare, Tokyo, Japan

Synopsis

There are two approaches proposed to calculate cerebral blood flow (CBF) and arterial transit time (ATT) accurately, while ensuring sufficient SNR. One is time-encoded (TE) and the other is sequential variable-TR (vTR) pseudo-continuous arterial spin labeling (PCASL). In this study, we measured SNR, CBF, and ATT from these two methods and compared and verified their validity in 5 healthy subjects. The higher SNR was secured in TE-PCASL compared to vTR-PCASL. On the other hand, ATT calculated from vTR-PCASL showed higher correlation coefficient with reference compared with TE-PCASL. The CBF calculated from both schemes showed high correlation coefficient with reference.

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