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Abstract #4618

Quantitative evaluation of cartilage damage in hemophiliac arthropathy using automatic segmentation of 3D high resolution MRI images

Jiajia Li1, Shufang Wei1, Xianchang Zhang2, Jing An3, Esther Raithel4, and Yinghui Ge1
1Fuwai Central China Cardiovascular Hospital, Zhengzhou, China, 2MR Collaboration, Siemens Healthineers Ltd, Beijing, China, 3Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 4Siemens Healthcare GmbH, Erlangen, Germany


Hemophilic arthropathy (HA) is a serious complication of haemophilia, characterized by bone and cartilage damage due to recurrent joint bleeding. Existing evidence showed HA has a fast disease progression. MRI-based evaluation plays an important role in the detection, categorization and staging of soft tissue and osteochondral changes in HA, which is important for assessing and monitoring treatment outcomes. However, currently semi-quantitative scoring system based on conventional MRI images cannot give an objective assessment of knee cartilage damage. To this end, this study for the first time used an automatic segmentation algorithm to quantitatively evaluate the morphological change of knee cartilage in HA.

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