Recent advances in UTE-MRI techniques development allow for quantitative measurements of tissues with very short T2. However, in vivo experiments are needed to extend its application in clinical practice. In this in vivo study, we found that both UTE-MTR and UTE-adiabatic-T1rho values indicated a moderate correlation with MOAKS Grading. Meanwhile, both of them had moderate diagnostic efficacy for the mild cartilage degeneration (MOAKS = 1). These findings suggested that quantitative UTE-MRI techniques have a great potential as imaging biomarkers for early OA diagnosis in clinic.
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