Abstract #4624

MIXTURE-DOSMA: Initial clinical research of a comprehensive and multi-parametric quantitative 3D knee MR exam in patients with knee joint pain.

Takayuki Sakai¹, Jihun Kwon², Masami Yoneyama², Daichi Murayama¹, Quin Lu³, Arjun Desai⁴, Akshay S Chaudhari⁵, Tosiaki Miyati⁶, Shigehiro Ochi¹, and Atsuya Watanabe^7,8

¹Radiology, Eastern Chiba Medical Center, Chiba, Japan, ²Philips Japan, Tokyo, Japan, ³Philips Healthcare NA, San Francisco, CA, United States, ⁴Electrical Engineering, Stanford University, Stanford, CA, United States, ⁵Radiology, Stanford University, Stanford, CA, United States, ⁶Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, ⁷General Medical Services, Chiba University Graduate School of Medicine, Chiba, Japan, ⁸Orthopaedic Surgery, Eastern Chiba Medical Center, Chiba, Japan

Synopsis

Multi-Interleaved X-prepared TSE with inTUitive RElaxometry (MIXTURE) is a recently developed 3D magnetization-prepared turbo spin-echo sequence. MIXTURE provides 3D high-resolution isotropic knee morphometry and T1ρ relaxometry in a clinically reasonable scan time. In this study, we integrated MIXTURE with the into a Deep-learning, Open-Source Medical Analysis (DOSMA) framework for deep learning-powered musculoskeletal MR image and evaluated its clinical usefulness in patients with knee joint pain. We show that the combination of MIXTURE and DOSMA enables a comprehensive whole knee MR exam including 3D isotropic submillimeter imaging, T2- and T1ρ-mapping, and standardized image analysis. The clinical insight MIXTURE-DOSMA brings is demonstrated.

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