MIXTURE-DOSMA: Initial clinical research of a comprehensive and multi-parametric quantitative 3D knee MR exam in patients with knee joint pain.
Takayuki Sakai1, Jihun Kwon2, Masami Yoneyama2, Daichi Murayama1, Quin Lu3, Arjun Desai4, Akshay S Chaudhari5, Tosiaki Miyati6, Shigehiro Ochi1, and Atsuya Watanabe7,8
1Radiology, Eastern Chiba Medical Center, Chiba, Japan, 2Philips Japan, Tokyo, Japan, 3Philips Healthcare NA, San Francisco, CA, United States, 4Electrical Engineering, Stanford University, Stanford, CA, United States, 5Radiology, Stanford University, Stanford, CA, United States, 6Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 7General Medical Services, Chiba University Graduate School of Medicine, Chiba, Japan, 8Orthopaedic Surgery, Eastern Chiba Medical Center, Chiba, Japan
Multi-Interleaved X-prepared TSE with inTUitive RElaxometry (MIXTURE) is a recently developed 3D magnetization-prepared turbo spin-echo sequence. MIXTURE provides 3D high-resolution isotropic knee morphometry and T1ρ relaxometry in a clinically reasonable scan time. In this study, we integrated MIXTURE with the into a Deep-learning, Open-Source Medical Analysis (DOSMA) framework for deep learning-powered musculoskeletal MR image and evaluated its clinical usefulness in patients with knee joint pain. We show that the combination of MIXTURE and DOSMA enables a comprehensive whole knee MR exam including 3D isotropic submillimeter imaging, T2- and T1ρ-mapping, and standardized image analysis. The clinical insight MIXTURE-DOSMA brings is demonstrated.
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