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Abstract #4630

Associations and mediation effects analysis of cortical porosity index, CKD stages, and bone metabolism markers

Yan Xiong1, Shuang Hu1, Yao Zhang 1, Donglin Wen1, Weiyin Vivian Liu2, and Xiaoming Li 1
1Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2GE Healthcare, Beijing, China


Chronic kidney disease (CKD) has a significant negative impact on bone health. However, the mechanisms of cortical bone deterioration and cortical porosity enlargement caused by CKD have not been fully described. Double-echo ultrashort echo-time magnetic resonance imaging (UTE MRI) provides the possibility of quantifying cortical porosity in vivo. The increasing CKD stages were associated with a higher PI value (Ptrend < 0.001). The association of CKD stages and PI mediated 34.4% and 30.8% of the total effect by increased PTH and β-CTX, respectively. Our study revealed the internal mechanism of bone deterioration caused by CKD to some extent.

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