Our study investigated the feasibility of LiverLab technique, consisted of multi-echo DIXON and HISTO, to evaluate the vertebral BMFF and iron content for the diagnosis of osteoporosis. BMFF measured by multi-echo DIXON and HISTO was significantly increased in osteoporosis patients and strong negative correlation with BMD. Vertebral iron content had no difference in osteoporosis patients and no correlation with BMD. LiverLab technique, composed of multi-echo DIXON and HISTO, can quantitatively evaluate the changes in bone marrow fat content, and can be used as a potential biomarker for evaluating abnormal bone density and severity of osteoporosis.
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