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Abstract #4631

Application of Multi-echo DIXON and HISTO to evaluate bone marrow fat/iron content in lumbar osteoporosis patients

Yang Wang1, Fengyu Sun1, Chen Zhang2, Haoran Sun1, Dong Li1, and Yuezeng Cai1
1Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China, 2MR Scientific Marketing, Siemens Healthineers, Beijing, China


Our study investigated the feasibility of LiverLab technique, consisted of multi-echo DIXON and HISTO, to evaluate the vertebral BMFF and iron content for the diagnosis of osteoporosis. BMFF measured by multi-echo DIXON and HISTO was significantly increased in osteoporosis patients and strong negative correlation with BMD. Vertebral iron content had no difference in osteoporosis patients and no correlation with BMD. LiverLab technique, composed of multi-echo DIXON and HISTO, can quantitatively evaluate the changes in bone marrow fat content, and can be used as a potential biomarker for evaluating abnormal bone density and severity of osteoporosis.

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