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Abstract #4638

MIXTURE-DOSMA: A comprehensive and multi-parametric quantitative 3D knee MR exam in 10 minutes

Jihun Kwon1, Takayuki Sakai2, Masami Yoneyama1, Daichi Murayama2, Quin Lu3, Arjun D Desai4, Akshay S Chaudhari5, and Marc Van Cauteren6
1Philips Japan, Tokyo, Japan, 2Department of Radiology, Eastern Chiba Medical Center, Chiba, Japan, 3Philips Healthcare NA, San Francisco, CA, United States, 4Electrical Engineering, Stanford University, Stanford, CA, United States, 5Radiology, Stanford University, Stanford, CA, United States, 6Philips Healthcare, Best, Netherlands


Multi-Interleaved X-prepared TSE with inTUitive RElaxometry (MIXTURE) is a recently developed 3D magnetization-prepared turbo spin-echo sequence. MIXTURE provides 3D high-resolution isotropic knee morphometry and T1ρ relaxometry in a clinically reasonable scan time. In this study, we integrated MIXTURE with the Deep Open-Source Medical Analysis (DOSMA) framework for deep learning-powered musculoskeletal MR image analysis to expand its clinical usage. By exploiting the advantage of both techniques, we show that the combination of MIXTURE and DOSMA enables a comprehensive whole knee MR exam including 3D proton density-weighted isotropic submillimeter imaging, T2- and T1ρ-mapping, and standardized image analysis techniques.

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