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Abstract #4639

Correlating Raised Intracranial Pressure with Increased ­Brain Motion in a Ovine Model

Alice Little1, Eryn Kwon1,2,3, Soroush Safaei2, Gonzalo Maso Talou2, David Dubowitz1, Miriam Scadeng1,3, Sarah-Jane Guild2,4, and Samantha Holdsworth1,3
1Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland, New Zealand, 2Auckland Bioengineering Institute, Auckland, New Zealand, 3Mātai Medical Research Institute, Gisborne, New Zealand, 4Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand


Heartbeat-driven brain motion has historically remained limited to the domain of research. Such motion may provide a window into conditions that alter the brain pressure where direct, invasive measurements are difficult to justify. Amplified MRI (aMRI) is a recently developed method which amplifies subtle brain motion, providing high temporal resolution and high contrast ‘videos’ of brain motion patterns. In an ovine model of elevated intracranial pressure we show preliminary data that aMRI can be used to detect changes in brain motion associated with pressure, indicating potential to provide non-invasive insight into the mechanical changes in patients with altered intracranial pressure.

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