(ISMRM 2022) <h2 align="justify" style="text-align: justify;"><b>T2/T1-weighted MRI revealed the therapeutic role of microglial SMAD7 in a traumatic brain injury (TBI) mouse model</b></h2>

Abstract #4640

T2/T1-weighted MRI revealed the therapeutic role of microglial SMAD7 in a traumatic brain injury (TBI) mouse model

Yang Ruan¹, Yimin Huang², Xuejun He², Huaqiu Zhang², and Hongxia Lei¹

¹Wuhan United Imaging Life Science Instrument Co., Ltd., China, Wuhan, China, ²Department of Neurosurgery, Tongji Hospital, Tongji Medical College,, Huazhong University of Science and Technology, Wuhan, China

Synopsis

We applied T2/T1-weighted MRI together with behavior, Hematoxylin&Eosin（HE）and immunohistochemistry fluorescence staining (IHC) to evaluate the role of microglial SMAD7, a novel therapeutic approach, in a TBI mouse model. The consistency between MRI results and behavior and myelin and neurnal marker outcomes suggest that the protective role of over-expression of microglial SMAD7 in TBI.

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