T2/T1-weighted MRI revealed the therapeutic role of microglial SMAD7 in a traumatic brain injury (TBI) mouse model
Yang Ruan1, Yimin Huang2, Xuejun He2, Huaqiu Zhang2, and Hongxia Lei1
1Wuhan United Imaging Life Science Instrument Co., Ltd., China, Wuhan, China, 2Department of Neurosurgery, Tongji Hospital, Tongji Medical College,, Huazhong University of Science and Technology, Wuhan, China
We applied T2/T1-weighted MRI together with behavior, Hematoxylin&Eosin（HE）and immunohistochemistry fluorescence staining (IHC) to evaluate the role of microglial SMAD7, a novel therapeutic approach, in a TBI mouse model. The consistency between MRI results and behavior and myelin and neurnal marker outcomes suggest that the protective role of over-expression of microglial SMAD7 in TBI.
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