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Abstract #4641

Quantifications of Relative Cerebral Blood Volume and MRS metabolites in Aging Collapsin Response Mediator Protein 1 Gene Knockout Mice

Tzu-Ming Hung1, Sheng-Min Huang2, Yun-Chieh Tsai3, Ting-Yu Chin4, and Hsu-Hsia Peng1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, Hsinchu, Taiwan, 2Institute of biomedical engineering and nanomedicine, National Health Research Institutes, Miaoli, Taiwan, Miaoli, Taiwan, 3Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City 114, Taiwan, Taipei, Taiwan, 4Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City 320, Taiwan, Taoyuan, Taiwan


Aging and collapsin response mediator protein 1 (CRMP-1) gene knockout (KO) mice may exhibit neural disorganization in hippocampus and demonstrate memory and spatial learning dysfunction. The purpose of this study was to quantify relative cerebral blood volume (rCBV) and MRS metabolites in hippocampus in wild type and aging CRMP-1 KO mice. There was no significant difference of rCBV value between the two groups. In comparison with wild type (WT) mice, KO mice possessed significant lower Glx/t-Cr level in hippocampus, illustrating the altered neural transmission function in aging CRMP-1 KO mice.

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