Abstract #4641

Quantifications of Relative Cerebral Blood Volume and MRS metabolites in Aging Collapsin Response Mediator Protein 1 Gene Knockout Mice

Tzu-Ming Hung¹, Sheng-Min Huang², Yun-Chieh Tsai³, Ting-Yu Chin⁴, and Hsu-Hsia Peng¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, Hsinchu, Taiwan, ²Institute of biomedical engineering and nanomedicine, National Health Research Institutes, Miaoli, Taiwan, Miaoli, Taiwan, ³Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City 114, Taiwan, Taipei, Taiwan, ⁴Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City 320, Taiwan, Taoyuan, Taiwan

Synopsis

Aging and collapsin response mediator protein 1 (CRMP-1) gene knockout (KO) mice may exhibit neural disorganization in hippocampus and demonstrate memory and spatial learning dysfunction. The purpose of this study was to quantify relative cerebral blood volume (rCBV) and MRS metabolites in hippocampus in wild type and aging CRMP-1 KO mice. There was no significant difference of rCBV value between the two groups. In comparison with wild type (WT) mice, KO mice possessed significant lower Glx/t-Cr level in hippocampus, illustrating the altered neural transmission function in aging CRMP-1 KO mice.

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