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Abstract #4642

Detection of cranial nerve degeneration in a transgenic Parkinson’s disease model marmoset using multi-contrast mechanism MRI

Junichi Hata1,2,3, Reona Kobayashi2, Yawara Haga2, Mai Mizumura1, Hinako Oshiro1, Kanako Muta1, Naoya Hayashi2, Daisuke Yoshimaru3, Kei Hagiya2, Hirotaka James Okano3, and Hideyuki Okano2
1Tokyo Metropolitan University, Tokyo, Japan, 2RIKEN Center for Brain Science, Saitama, Japan, 3The Jikei University, School of Medicine, Tokyo, Japan

Synopsis

In this study, we evaluated the characteristics of the brain in a genetically modified marmoset model of Parkinson’s disease. Various contrast mechanism images were acquired using magnetic resonance imaging (MRI), and the whole brain underwent explorative investigation with each contrast. This study was evaluated for Parkinson’s disease marmoset by anatomical MRI, neural fiber tractography and awakening state functional MRI. Malti-contrast MRI showed diseases characteristics in the thalamus, the nigral striatum, motor circuit and anymore. The findings suggest that the marmoset is useful as a model animal to study human diseases.

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Keywords