High-resolution multimodal imaging of the embryonic and neonatal mouse
Tomokazu Tsurugizawa1,2,3, Takuma Kumamoto4, Daisuke Yoshimaru5, and Yoshichika Yoshioka6
1Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, 2Faculty of Engineering, University of Tsukuba, Tsukuba, Japan, 3Center for Information and Neural Networks (CiNet), Osaka University and National Institute of Information and Communications Technology (NICT), Osaka, Japan, 4Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, 5Division of Regenerative Medicine, Jikei University school of Medicine, Tokyo, Japan, 6Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
The potential of magnetic resonance microscopy is to image the multimodal function of the brain in small brain, such as embryo. In this study, we developed high resolution imaging of T1 image, T2 mapping, mean diffusivity, and neurite orientation dispersion by diffusion MRI in embryo and early postnatal (P07) in mouse. These values were different between embryo and early postnatal. Immunohistochemistry revealed distinct proliferation and maturation of neurons and astrocytes in these stages. These results indicate the possibility of high-resolution MR microscopy to detect the cellular maturation in development.
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