Abstract #4643

High-resolution multimodal imaging of the embryonic and neonatal mouse

Tomokazu Tsurugizawa^1,2,3, Takuma Kumamoto⁴, Daisuke Yoshimaru⁵, and Yoshichika Yoshioka⁶

¹Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, ²Faculty of Engineering, University of Tsukuba, Tsukuba, Japan, ³Center for Information and Neural Networks (CiNet), Osaka University and National Institute of Information and Communications Technology (NICT), Osaka, Japan, ⁴Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, ⁵Division of Regenerative Medicine, Jikei University school of Medicine, Tokyo, Japan, ⁶Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

Synopsis

The potential of magnetic resonance microscopy is to image the multimodal function of the brain in small brain, such as embryo. In this study, we developed high resolution imaging of T1 image, T2 mapping, mean diffusivity, and neurite orientation dispersion by diffusion MRI in embryo and early postnatal (P07) in mouse. These values were different between embryo and early postnatal. Immunohistochemistry revealed distinct proliferation and maturation of neurons and astrocytes in these stages. These results indicate the possibility of high-resolution MR microscopy to detect the cellular maturation in development.

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