Abstract #4649

IVIM and DCE MRI to early detect hepatic injury and microcirculation alteration induced by intestinal ischemia reperfusion in a rat model

jiaxing yang¹, Weiqiang Dou², changjie pan³, and haifeng shi³

¹Radiology, The Affiliated ChangzhouNo.2 People's Hospital of Nanjing Medical University, Changzhou, China, ²MR Research China, Beijing, China, ³The Affiliated ChangzhouNo.2 People's Hospital of Nanjing Medical University, Changzhou, China

Synopsis

This study demonstrated that intravoxel incoherent motion (IVIM) and dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) can effectively estimate hepatic pathophysiological processes in a rat model with intestinal ischemia reperfusion (IIR) induced hepatic injury. The changes in microcirculation and perfusion were considered the major factors of IIR-induced hepatic injury. IVIM derived parameters of f and D* as well as DCE related parameter of V_e and K^transrevealed high sensitivity to histological change, implying that IVIM and DCE-MRI might be an effective tool to evaluate the process of IIR-induced hepatic injury.

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