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Abstract #4648

Influence of gadoxetate disodium to the liver fat fraction quantified with Dixon sequences in rabbits

Zhe Huang1, Yu Jiang#1, Xia Wang#1, Sheng Zhang#1, Heng Li#1, and Dong Yue Han*1
1Department of Radiology, Xi’an GaoXin Hospital, Xi’an Jiao Tong University, Xi’an, China


A study was carried out on the effect of Gadoxetate disodium (Gx) on the accuracy of liver fat content determined by 2-echos and 6-echos VIBE Dixon in rabbits with nonalcoholic fatty liver disease in hepatobiliary specific phase. Proton density fat-fraction (PDFF) before and 13min. and 17min. after Gx enhancement had strong correlation with that of histopathology (r22E= 0.7643-0.8014 vs. r26E= 0.8208-0.8536). PDFF measured by 6E-VIBE Dixon was stable and reliable, especially for that before Gx enhancement(r26E= 0.8536). PDFF measured by 2E-VIBE Dixon fluctuated to some extent, however, it could be effectively corrected in the specific hepatobiliary phase after Gx enhancement.

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