Tales of Two Environments: Enriched Mice show Stronger Sensory Evoked BOLD fMRI Responses, while Socially Isolated Ones Respond Less
Taekwan Lee1, Taeyi You2,3, Geun Ho Im3, Seong-Gi Kim2,3,4, Sungkwon Chung5, and Jung Hee Lee2,3,6
1Korea Brain Research Institute, Daegu, Korea, Republic of, 2Biomedical Engineering, Sungkyungkwan University, Suwon, Korea, Republic of, 3Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 4Intelligent Precision Healthcare Convergence, Sungkyungkwan University, Suwon, Korea, Republic of, 5Physiology, Sungkyunkwan University, Suwon, Korea, Republic of, 6Radiology, Sungkyungkwan University, Suwon, Korea, Republic of
It is well known environmental factors can affect brain plasticity in humans, yet finding strong correlative factors is difficult due to the long development and complexity of human research. Mouse enrichment studies allows for better controlled research and by combining it with fMRI, makes mapping brain-wide plasticity changes possible. Here, we treated mice into three groups of enrichment, standard caging, and isolated caging to see how their brain responds to multiple-sensory stimulations. We found the enrichment group responded stronger in multimodal midbrain and thalamic areas. The isolated group responded less suggesting mouse fMRI is viable in detecting plasticity changes.
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