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Abstract #4658

Noninvasive Assessment of Chronic Hepatitis B with Different Courses or Liver Cirrhosis Patients Receiving Interferon Therapy Using T1ρ Mapping

Yufei Zhao1 and Xingui Peng1
1Southeast University, Nanjing, China


The staging of chronic hepatitis B mainly relies on invasive pathological biopsy, interferon treatment can reduce the risk of deterioration. 93 patients were divided into three groups: mild, moderate, severe or liver cirrhosis according to histopathology and received T1ρ magnetic resonance liver scan before and after interferon treatment. With the aggravation of chronic hepatitis B, T1ρ relaxation time gradually increased, but it decreased significantly after treatment, which is linearly correlated with the level of ALT and AST. T1ρ magnetic resonance can non-invasively assess the severity of the chronic hepatitis B and monitor the improvement of fibrosis after receiving treatment dynamically.

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