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Abstract #4665

Radiomics Analysis Based on IVIM-DWI for Early Assessment of Transplanted Kidney Dysfunction

Xiaodong Liu1, Lihua Chen1, Wen Shen1, Kun Zhang1, Xiaodong Ji1, Robert Grimm2, and Jinxia Zhu3
1Department of Radiology, Tianjin First Central Hospital, Tianjin, China, 2MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 3MR Collaboration, Siemens Healthcare Ltd., Beijing, China

Synopsis

This study investigated the feasibility of predicting early renal function impairment after renal transplantation based on an intravoxel incoherent motion imaging (IVIM)diffusion weighted imaging (DWI)radiomics model. For noninvasive detection of kidney function impairment at an early stage, IVIM-DWI applies a bi-exponential model to evaluate both capillary perfusion and tissue diffusion. The overall accuracy of the radiomics model was 79.3%, with 73.3% sensitivity and 85.7% specificity in distinguishing renal function impairment after renal transplantation. These results demonstrate the potential of a radiomics model for a reliable non-invasive diagnosis of renal transplant function.

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