Abstract #4671

Assessment of intra-tumoral heterogeneity of prostate cancer using Intravoxel Incoherent Motion (IVIM)

Sirisha Tadimalla¹, Yu-Feng Wang¹, Yu Sun¹, Jonathan Goodwin², Robba Rai^3,4,5, Sheryl Foster^6,7, and Annette Haworth¹

¹Institute of Medical Physics, The University of Sydney, Sydney, Australia, ²Department of Radiation Oncology, Calvary Mater Hospital, Waratah, Australia, ³South Western Sydney Clinical School, University of New South Wales, Sydney, Australia, ⁴Liverpool and Macarthur Cancer Therapy Centre, Liverpool, Australia, ⁵Ingham Institute of Applied Medical Research, Liverpool, Australia, ⁶Faculty of Medicine and Health, The University of Sydney, Sydney, Australia, ⁷Department of Radiology, Westmead Hospital, Westmead, Australia

Synopsis

Mapping the intra-tumoral heterogeneity of perfusion before and after treatment offers the opportunity to identify hypoxic regions in the tumour and predict recurrent disease. Intravoxel Incoherent Motion (IVIM) parametric maps were obtained in patients with prostate cancer before and after radiation therapy. IVIM shows potential for the assessment of intra-tumoral heterogeneity of perfusion in prostate cancer.

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