Assessment of intra-tumoral heterogeneity of prostate cancer using Intravoxel Incoherent Motion (IVIM)
Sirisha Tadimalla1, Yu-Feng Wang1, Yu Sun1, Jonathan Goodwin2, Robba Rai3,4,5, Sheryl Foster6,7, and Annette Haworth1
1Institute of Medical Physics, The University of Sydney, Sydney, Australia, 2Department of Radiation Oncology, Calvary Mater Hospital, Waratah, Australia, 3South Western Sydney Clinical School, University of New South Wales, Sydney, Australia, 4Liverpool and Macarthur Cancer Therapy Centre, Liverpool, Australia, 5Ingham Institute of Applied Medical Research, Liverpool, Australia, 6Faculty of Medicine and Health, The University of Sydney, Sydney, Australia, 7Department of Radiology, Westmead Hospital, Westmead, Australia
Mapping the intra-tumoral heterogeneity of perfusion before and after treatment offers the opportunity to identify hypoxic regions in the tumour and predict recurrent disease. Intravoxel Incoherent Motion (IVIM) parametric maps were obtained in patients with prostate cancer before and after radiation therapy. IVIM shows potential for the assessment of intra-tumoral heterogeneity of perfusion in prostate cancer.
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